Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators

  • Posted on: 25 March 2021
  • By: ygfoehler
TitleSuitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators
Publication TypeJournal Article
Year of Publication2021
AuthorsLukitsch B, Ecker P, Elenkov M, Janeczek C, Jordan C, Krenn CG, Ullrich R, Gfoehler M, Harasek M
Date Published03/2021

CO2 removal via membrane oxygenators during lung protective ventilation has become areliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO2removal rate is necessary. It can either be determined by measuring the CO2 content in the exhaustgas of the oxygenator (sweep flow‐based) or using blood gas analyzer data and a CO2 solubilitymodel (blood‐based). In this study, we determined the CO2 removal rate of a prototype oxygenatorutilizing both methods in in vitro trials with bovine and in vivo trials with porcine blood. While thesweep flow‐based method is reliably accurate, the blood‐based method depends on the accuracy ofthe solubility model. In this work, we quantified performances of four different solubility modelsby calculating the deviation of the CO2 removal rates determined by both methods. Obtained datasuggest that the simplest model (Loeppky) performs better than the more complex ones (May, Sig‐gaard‐Anderson, and Zierenberg). The models of May, Siggaard‐Anderson, and Zierenberg showa significantly better performance for in vitro bovine blood data than for in vivo porcine blood data.Furthermore, the suitability of the Loeppky model parameters for bovine blood (in vitro) and por‐cine blood (in vivo) is evaluated. 

Short TitleBioengineering